|
KMID : 0620920090410030208
|
|
Experimental & Molecular Medicine
2009 Volume.41 No. 3 p.208 ~ p.216
|
|
|
B cell activation factor (BAFF) is a novel adipokine that links obesity and inflammation
|
|
Kim Yu-hee
Choi Bong-Hyuk
Cheon Hyae-Gyeong
Do Myoung-Sool
|
|
|
Abstract
|
|
|
|
B cell activation factor (BAFF) is a novel member of the TNF ligand superfamily, mainly produced by myeloid cells. BAFF has been shown to participate in B-cell survival and B- and T-cell maturation. BAFF expression in adipocytes has been recently demonstrated. In the current study, we verified that BAFF expression is increased during adipocyte differentiation. BAFF expression was augmented by TNF-α treatment and was decreased by rosiglitazone treatment. BAFF secretion in lean and in ob/ob mice sera were compared and smaller amount of BAFF was secreted in ob/ob mice. mRNA and protein expression were different between epididymal and visceral adipose tissue. BAFF expression was also increased in ob/ob mouse adipose tissue. We sought to identify known BAFF receptors (BAFF-R, BCMA, and TACI) in adipocytes, and determined that all three were present and upregulated during adipocyte differentiation. However, the expression of TACI was distinct from that of BAFF-R and BCMA under TNF-α and BAFF ligand treatment. BAFF-R and BCMA expression levels were upregulated under pro-inflammatory conditions, but TACI was reduced. Conversely, BAFF-R and BCMA expression levels were downregulated by rosiglitazone treatment, but TACI was increased. Taken together, our results suggest that BAFF may be a new adipokine, representing a link between obesity and inflammation.
|
|
|
KEYWORD
|
|
|
adipokine, B-cell maturation antigen, obesity, rosiglitazone, TNFRSF13C protein, human, TNFSF13B protein, human, transmembrane activator and CAML Interactor protein
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
    
|
|